One of the most common combinations, a triple therapy with a combination of intravenous PMT, oral CPA, and alternate-day prednisone therapy, was first described by Griswold. Large doses, 30 mg/kg methylprednisolone up to a maximum of 1 g, were infused intravenously three times per week for 2 weeks (six doses) and then weekly for at least 4–6 weeks.

Decreasing the frequency of the PMT dose to every other week and monthly occurred when UProt/UCreat levels decreased to near normal levels. For patients who did not respond to pulse intravenous corticosteroid therapy (PICT) alone, oral CPA at 2 mg/kg/day was prescribed for 75–90 days. Alternate-day oral corticosteroid dosing was decreased relative to the patient’s response.

Nitrogen mustard therapy (mechlorethamine) and vincristine There have been no RCTs of mechlorethamine. Mechlorethamine therapy with corticosteroids or adrenocorticotropic hormone was advocated as an effective treatment for SRNS from the 1950s to the 1980s.

All patients achieved partial or complete remission in the study conducted by Fine, in which mechlorethamine was infused intravenously for four consecutive days. A subsequent study by Armugan did not report encouraging results.

None of the seven patients achieved a complete remission. Vomiting was a common adverse effect of mechlorethamine therapy. although primarily used as an antineoplastic drug in the treatment of malignancies, there have been two small cohort studies of vincristine treatment in children with SRNS. Response rates to therapy, defined as combined complete and partial remissions, were 38% and 43%.  

Both studies concluded that vincristine was relatively ineffective in inducing remission. However, patient selection for both studies appeared to be biased towards unresponsiveness to any therapy. There is insufficient evidence to make a recommendation regarding vincristine therapy.  

In the six triple therapy studies (150 patients), 50–75% of patients achieved a complete or partial remission. African American patients may be less responsive to triple therapy than other ethnic groups, and outcomes in patients who have failed treatment with calcineurin inhibitors have been disappointing. A long-term analysis of FSGS patients by Tune reported that 9% of patients progressed to ESRD.

Steroid-resistant Nephrotic Syndrome Other Antineoplastic and Immunosuppressant MedicationsHow to Identify Anorexia Nervosa Symptoms. Adverse effects, including transient hypertension, vomiting, steroid-induced cataracts, and headaches, are reported to be self limited. RCTs are needed to determine the effectiveness and safety of this therapy.

Waldo conducted a prospective cohort study in which PMT and CsA therapy was combined in 10 children with FSGS, 80% of whom achieved remission. Four of the patients were African American, and all four responded to therapy. Yorgin also reported the use of combined PMT, angiotensin converting enzyme inhibitor (ACEi), and CsA therapy in a subset of study subjects. CsA therapy was used to maintain remission after it had been achieved by PMT.

Kano reported the successful use of combination therapy with PMT, intravenous immunoglobulin and a statin, with 77% achieving a complete or partial remission.The study by Mori prospectively evaluated the use of heparin therapy and PMT administered for three consecutive days. The combination therapy was given 14 times over 2 years.

The patient group consisted of children who were expected to have a poor prognosis due to their resistance to CPA or CsA, and 60% achieved a partial or complete remission.El-Reshaid reported a 100% remission rate in 21 children with SRNS in a sequential protocol consisting of a calcineurin inhibitor followed by the addition of MMF and then by monthly intravenous CPA for three consecutive months. All patients required antihypertensive therapy after starting calcineurin inhibitor therapy.

The use of combination therapy, consisting of two or three different medications, has been advocated by many investigators. There have been at least 10 studies with a total of 204 patients treated with combination therapy, but no RCT has been conducted. The mean complete remission rate for all combination therapies is 58%. Nearly all patients with MCD respond to combination therapy,whereas only 47% of FSGS patients achieve a complete remission.  

Discovery Education Health CME: Fibromyalgia: From Diagnosis to Treatment DVD; Gr: 9 – 12; 52 min.
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fibromyalgia is a muscle and joint disease that affects approximately two to four percent of the population, fibromyalgia is predominantly diagnosed in women between 20 and 50, although it can affect men and even children. It’s estimated some twenty million Americans suffer from this disorder. Fibromyalgia is said to be the most common arthritis related condition after osteoarthritis.

 The cause of fibromyalgia is not clearly understood. Some researchers theorize decreased levels of serotonin contribute, while others think there’s a genetic or environmental component. Some researchers feel there is even a link between childhood abuse and the propensity to develop fibromyalgia. Many practicing physicians don’t even recognize fibromyalgia as a true diagnosis but most rheumatologists do. It can be difficult to find a medical practitioner sympathetic to the condition and familiar with its treatment.

Diagnosing Fibromyalgia is very difficult. It’s been called the great imitator because it’s often misdiagnosed as arthritis, Lyme disease and other disorders. The diagnosis is primarily made by ruling out other diseases and by symptoms reported by the patient.

Symptoms include muscle pain and stiffness lasting more than three months, sore throat, swollen glands and painful tissue with normal blood work, poor sleep and fatigue in the mornings. In addition, there are specific trigger points that are generally inflamed and tender. The symptoms of fibromyalgia can be aggravated by stress, cold, humidity, over exertion, lack of sleep and infections. Allergies to certain foods and things may also serve as triggers to cause an acute flare up of symptoms. Some research has suggested diet changes; including switching to a vegetarian lifestyle may be very helpful. Pain is the overriding symptom of fibromyalgia and as in many chronic pain disorders the risk of developing secondary addiction problems is high. A pain management doctor may be recommended. It may even be in the fibromyalgia suffers best interest to ask for a pain management referral as the FDA frowns on family doctors and internist prescribing chronic pain medication.

Treatment is a combination of modalities. Therapy to learn better coping mechanisms and decrease stress, finding medications and practices that improve sleep, changes in diet, gentle exercise and physical therapy have all proved to be of benefit. Various medications including serotonin reuptake inhibitors such Prozac, Tricyclic antidepressants such as Elavil, muscle relaxants such as Flexeril, non steroidal anti inflammatory drugs, and Cymbalta. Some physicians will order trigger point injections with some success in pain relief.

Fibromyalgia is a difficult condition both to diagnose and treat. Research is continuing in an attempt to develop better diagnostic and treatment options. At the present time treatment has only about a fifty percent success rate, however this can be improved by a combination approach that includes all the treatment modalities available.

http://www.sciencedaily.com/releases/2006/11/061128122416.htm

http://chronicfatigueandfibromyalgia.com/

http://www.fibromyalghttp://chronicfatigueandfibromyalgia.com/ia.com/pain_diary_excerpt.htm

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You hurt all over, and you often feel exhausted. Even after numerous tests, your doctor can’t find no matter which specially wrong with you. If this sounds familiar, you may have fibromyalgia.

Fibromyalgia is a chronic condition characterize by widespread pain in your muscles, ligaments and tendons, as well as fatigue and manifold tender points — places on your body where slight force causes pain.

Fibromyalgia makes you feel weary and causes power pain and “tender points.” Tender points are places on the neck, shoulder, back, hips, arms or legs that hurt when touched.

People with fibromyalgia may have other symptoms, such as trouble resting, morning stiffness, headaches, and evils with accepted wisdom and memory, from time to time called “fibro fog.”

No one knows what causes fibromyalgia. Anyone can get it, but it is most ordinary in middle-aged women.

People with rheumatoid arthritis and other autoimmune diseases are chiefly likely to develop fibromyalgia.

There is no cure for fibromyalgia, but medicine can help you run your symptoms. Getting enough sleep and exercise may also help.

Causes of Fibromyalgia

While the original cause or causes of FM still remain a mystery, new research answer continue to bring us closer to sympathetic the basic mechanism of fibromyalgia.

Most researchers agree that FM is a disorder of central meting out with neuroendocrine/neurotransmitter deregulations.

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The suggested causes include:

1.    Overexertion
2.    Stress
3.    Lack of exercise
4.    Anxiety
5.    Depression
6.    Lack of sleep or sleep disturbances
7.    Trauma
8.    Extremes of temperature and/ or humidity
9.    Infectious illness.

Symptoms of Fibromyalgia

1.     Chronic muscle pain, muscle spasms or tightness, weakness in the limbs, and leg cramps
2.     Moderate or severe exhaustion and decrease energy
3.     Insomnia or waking up feeling just as tired as when you went to sleep
4.     Stiffness upon waking or after staying in one position for too long
5.     Difficulty remembering, concentrating, and performing simple mental tasks
6.     Abdominal pain, bloating, nausea, and constipation alternating with diarrhea (irritable bowel syndrome)
7.     Tension or migraine headaches
8.     Jaw and facial tenderness
9.     Sensitivity to one or more of the following: odors, noise, bright lights, medications, certain foods, and cold

Treatment of Fibromyalgia

Traditional treatment of fibromyalgia is geared toward civilizing the excellence of sleep and plummeting pain, which means that a sleep study may aid with individualizing your therapy.

Deep level (stage 4) sleep is crucial for many body functions (such as tissue repair, antibody manufacture, and the rule of various neurotransmitters, hormones and immune system chemicals).

Therefore, treatment of the sleep disorder that often occur in fibromyalgia patients are usually address first because disturbed sleep may be a strong causal factor to your symptoms.

1.    Common sleep-aid medications include Ambien, Lunesta, clonazepam, and trazodone.

2.    Ultram may help with the action of fibromyalgia pain, although stronger opioids may be needed for address moderate to severe pain.

Home Remedies for Fibromyalgia

1.    Take balanced diet counting plenty of roughage, cabbage, salads, carrot, reddish, etc. Patient be supposed to also take plenty of fluid like plain water and freshly prepared juice in the diet.

2.    Coconut water and coconut milk is also good for fibromyalgia.

3.    Restrict your eating of sweets and sugar contain foods.

4.    Exercise and meditation are very important for the fibromyalgia patients.

5.    Try to live a stressful life.

6.     Take correct sleep of at least 7-8 hours.

7.     Prepare a combination of olive oil and kerosene oil in equal quantity and massage gently 2-3 times a day for a month.

8.     Apply warm vinegar over the affected muscles.

9.     Avoid excess intake of oily or junk food.

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Are you suffering from pain all over the body and irritable bowel? You may have fibromyalgia, a disorder characterized by widespread musculoskeletal pain accompanied by fatigue, sleep memory and mood issues.

there is an alternative treatment for Fibromyalgia that helps control these symptoms.

The symptoms of fibromyalgia are: 1) pain all over 2) fatigue 3) brain fog 4) trouble sleeping 5) exercises difficulties 6) irritable bowel 7) headaches jaw pains 9) multiple sensitivities. These symptoms arise from causes such as genetics, infections and physical or emotional trauma.

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Alternative treatment for this syndrome makes effective use of herbal remedies and simple home remedies. This treatment is preferred to conventional treatment as it is simple, cheap and without side effects. If left untreated this disorder may lead to complications like inability to function normally at home or office, depression and health-related anxiety.

Fresh vegetable juices, coconut water, spices like cumin, coriander, ginger, asafetida and turmeric, cooked vegetables like squash, zucchini and pumpkin, green salads and drinking plenty of liquids are suggested as dies for the patients.

Patient should avoid eating hot, spicy and fried foods, sweets, foods like brinjal, cabbage, cauliflower, okra and potatoes and too much tea, coffee, alcohol, white sugar, yogurt, chocolate and cocoa. Sleeping during day and staying up late at night and mental tensions should also be avoided.

Herbal remedies like arthcare oil, shallaki, ashwagandha, ginger, garlic, menthol and camphor are very helpful in pain management. Epsom salt, stress reduction techniques, deep breathing, lymph drainage, taking saunas and warm baths and ginger tea are used in alternative treatment.

Meditation, yoga, pranayama and studying spiritual philosophy help in personal healing and relaxation of the mind.

If you know about alternative natural methods to cure fibromayalgia you can heal it at home.

http://www.fibromyalgia.cure4ever.com/

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fibromyalgia is an ailment which causes chronic pain in the body. Despite ongoing efforts by modern science, causes of fibromyalgia remain a great puzzle. Fibromyalgia is a very complex disorder and factors causing it remain a mystery. There are many symptoms related to fibromyalgia but leaves no physical traces which can help in diagnosis of this condition. Those suffering from fibromyalgia appear to be perfectly normal on being examined physically. Determining or singling out one single cause from among the many causes of fibromyalgia in an individual is very difficult if not impossible. The physical symptoms of fibromyalgia may include headache, dizziness, grinding teeth, facial pain, breathing problems, numbness or tingling sensations in extremities. Fibromyalgia pain medications render relief from all these painful situations, but they carry side effects of varying degrees.

Fibromyalgia symptoms not physical in nature is headed by depression, and could range from any of the following – memory loss, stress, confusion, mood swings, or anxiety. Perplexing symptoms and enshrouded in mystery to modern science makes fibromyalgia information an essential tool in recognizing and identifying this disease. Experts have yet to find any exact causes for fibromyalgia. But most experts agree towards a medical term – central sensitization or lower tolerance for pain. This is caused by the pain signals in the brain making a greater than normal impact on the body. It may surprise you but injuries of many types also list among the various causes of fibromyalgia.

Medications like muscle relaxants help decrease pain in people suffering from fibromyalgia but they cause side effects on prolonged use.

Most over the counter and prescription fibromyalgia pain medications carry side effects. This has prompted many people to go for alternative treatments for fibromyalgia which render wider benefits to the body in addition they offer no side effects. Most alternative treatments for fibromyalgia involve exercise. Gentle exercises including swimming and stretching help relieve fibromyalgia pain. But many patients avoid exercise as they find it boring or it tends to hurt them due to oversensitivity in the body. Massages are also popular among fibromyalgia patients as they offer a less strenuous way of achieving relief than exercising. Changing one’s diet and appropriate sleep are also effective approaches as alternative treatments for this disease. This approach can include supplements additions to daily diet as they aid in strengthening the immune system and along with bones and muscles. As fibromyalgia is counted to be a psychosomatic disease it also involves behavioral therapy. Here, doctors educate the patient in identifying specific areas of the body where the pain originates from. Besides, there are other natural remedies for fibromyalgia which have proven very beneficial to its patients, these include: meditation, yoga, exercise and a healthy lifestyle. Fibromyalgia can be best dealt with a combination of some or all the treatments discussed here. Once we identify a treatment that works best we can concentrate our efforts to get the most by making a strict treatment regimen and enjoy better health by sticking to it.

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Muscle cramps can temporarily disable even the fittest cyclist.  Every year at the Tour de France, several riders have to back off the fast pace and arduous climbing due to severe discomfort caused by cramping. Unfortunately, these unpredictable muscle spasms are somewhat mysterious, and it is difficult to understand what really causes them.

Cramps most commonly afflict cyclists who work their muscles to a point of exhaustion.  They can occur when you have an electrolyte imbalance, a low blood glucose level, or inadequacies in hydration, conditioning or flexibility.

The best training tip to address this problem is to do uphill intervals.  Attack a hill for 20-30 second, then recover briefly before doing it again.  This will improve our muscle strength and anaerobic endurance.  In addition, you should have your riding position checked at a qualified shop, since bike fit affects your muscles.  Also, periodically stand and stretch your quadriceps and calves while riding.

As far as dietary recommendations, it is critical that you avoid becoming dehydrated.  Water is ideal, but if the ride is longer than one hour, you may want to add a sports drink.  In hot weather, increase your fluid intake beyond the normal guideline of one standard water bottle.

During a ride, make sure to eat high carbohydrate foods to maintain your blood glucose level, and drink plenty of fluid to avoid dehydration.  After riding, rehydrate properly.  Have at least 3 glasses of water or energy drink.  Excess fluid poses no danger because it’s removed by body as urine.  Don’t drink beer or wine until you’re rehydrated.  Alcohol is a diuretic, causing fluid loss.  Energy drinks can help reduce cramping by providing electrolytes.  These are minerals (sodium, chloride, potassium) that carry an electrical charge that’s needed for muscle contractions and the maintenance of fluid levels.  Electrolytes are one reason potassium-rich bananas are often suggested as a cycling food. Maintain a diet rich in electrolytes.  These substances are essential for muscle contraction during exercise, and low levels have been associated with cramping.  For calcium, eat non-fat dairy products, tofu, dark green vegetables, and sardines.  For potassium, include fruits, juices, and vegetables, particularly squash, potatoes, beans, and mushrooms.  For magnesium, eat whole grains, nuts, dairy products, green vegetables, and legumes.

In a study conducted at the Hotter ‘n Hell Hundred in Texas, the medical staff found that the difference between crampers and non-crampers was magnesium.  The riders who cramped had less of it.  To determine if this deficiency is causing your problem, get a blood test either after a ride or after your cramping begins.

When a post-ride cramp does occur, immediately stretch the hamstring muscles by straightening your leg and bringing the toes of your foot toward your knee.  At the same time reach down and massage the area.  Believe it or not, a hard pinch on the upper lip may also provide immediate relief, although no one is certain why.  Some experts speculate that it causes an alteration in the neurotransmission from the brain to the muscle.  Whatever the reason, it often works.

If you try all these things and still cramp, see a sports medicine professional.

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If you suffer from fibromyalgia, you know how debilitating and persistent the symptoms can be! You may experience persistent muscle aches, fatigue, sleep disturbances, and frequent stiffness and joint discomfort.The
symptoms can be so severe and restricting that it’s difficult to complete simple daily tasks or hold down a full time job. Previously, the only effective class of drugs recommended for initial treatment of fibromyalgia have been antidepressants which don’t always provide adequate symptom relief. Plus, antidepressants can cause significant side effects in users including dry mouth, dizziness, excessive sleepiness, anxiety, and weight gain which can limit their usage.

A recent double-blind, controlled fibromyalgia study, presented at the American Academy of Neurology’s annual meeting, looked at the effects of a drug called pregabalin or Lyrica on the symptoms of 745 patients who had been diagnosed with fibromyalgia. The drug, although not yet approved specifically for use in fibromyalgia, was approved for use in the treatment of diabetic peripheral neuropathy and postherpetic neuralgia in 2004. This drug has proven to be effective and well tolerated for treatment of these two conditions and have been well tolerated, in general.

In this current study, Lyrica was found to relieve the chronic pain associated with fibromyalgia and improve the general quality of life for persons diagnosed with this difficult to treat disorder.Patients began to experience improvement in their levels of pain and fatigue as early as the first week on the new drug treatment. By the end of the study, many patients reported up to a 50% reduction in pain after treatment with Lyrica when compared with the placebo group. Lyrica also seemed to have positive effects on the sleep patterns of fibromyalgia sufferers and helped to reduce daytime fatigue. The most frequent side effects associated with the use of Lyrica were dizziness and excessive sleepiness.

If further studies support use of this drug to treat fibromyalgia, the consequences. could be far reaching. This disorder affects around 6 millions Americans and can cause significant disability and loss of productivity of untreated. At the present time, the cause of this disease has been undetermined.

This particular study was sponsored by the pharmaceutical company, Pfizer, which has an application pending for approval of Lyrica for treatment of fibromyalgia symptoms. If this drug is approved and goes into widespread use, could it be the answer to successfully treating fibromyalgia? Millions of fibromyalgia sufferers who experience symptoms on a daily basis certainly hope so!

If further studies support use of this drug to treat fibromyalgia, the consequences. could be far reaching. This disorder affects around 6 millions Americans and can cause significant disability and loss of productivity of untreated. At the present time, the cause of this disease has been undetermined.

This particular study was sponsored by the pharmaceutical company, Pfizer, which has an application pending for approval of Lyrica for treatment of fibromyalgia symptoms. If this drug is approved and goes into widespread use, could it be the answer to successfully treating fibromyalgia? Millions of fibromyalgia sufferers who experience symptoms on a daily basis certainly hope so!

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fibromyalgia is a chronic disease giving painful points in muscles and joint areas, stiffness and problems of neurological art like fatigue, poor sleep quality and depressive feelings. The disease develops gradually and can affect great parts of the body. It is chronic, but may give better and worse periods. The disease can make a person nearly disabled, but can also be mild or almost disappear over time.

THE SYMPTOMS OF fibromyalgia

By fibromyalgia there are tender points in muscles, tendons and ligaments around the body. The points are especially common around the joints. Tender areas in the mid parts of the muscles are fewer and with lighter pain. The points give a constant aching and a sharper pain by pressure. However, muscular work and exercise do not necessarily increase the pain. When the muscles are warmed up and exercised, the pain may disappear or decrease for some time.

The neck, shoulder area, hips, knee surroundings, jaw joint areas, head, face, and eye surroundings are especially often affected. When the neck and head area is affected, the pain often takes the form of a common headache.

Other symptoms of fibromyalgia are:

Muscular stiffness, especially in the morning.

Mental and physical fatigue.

Poor quality of sleep. The deep part of the sleep is especially affected.

Muscular tension.

Dizziness.

Anxious feelings.

Depressive feelings.

Disturbances in bowel function like diarrhoea, constipation, pain and bloating.

Bladder irritability.

Increased sensitivity to and irritability from sensorial stimuli, like light, sounds and touch.

Dry mouth, eyes and skin.

Pain during menstruation

The disease does not give any anatomical and tissue changes in the first place, but inactivity, tension and poor circulation may in the long run affect the body shape and give inflammatory reactions.

THE CAUSES AND MECHANISMS OF FIBROMYALGIA

The exact causes of fibromyalgia are not yet fully understood. An injury to the upper spinal region may trigger the disease. Bacterial and viral infections may also be an initial cause of the disease. Fibromyalgia sufferers often have a magnesium deficiency.

The initial causes seem to alter the production and secretion of transmitter substances in the brain and nervous system, especially serotonin, melatonin and substance P. Neurotransmitters carries signals from one nerve cell to another. Some signals from the central nervous system to the body may therefore be increased, and other decreased, producing the symptoms of the disease. The disturbed nerve signals then produce the following functional changes that give the symptoms of the disease:

An increased activity in brain parts, giving anxiety and disturbing the deep sleep.

A decreased activity in other brain parts, producing depressive symptoms.

An increased muscular tension during sleep.

An increased constriction in the blood vessels in the muscular and joint structures.

Decreasing blood flow in the muscles and joint areas due to increased muscular tension and blood vessel constrictions.

A decreased activity of glands producing saliva, sebum and tears.

LIFESTYLE MEASURES AND EXERCISE TO TREAT FIBROMYALGIA

It is difficult to find a treatment that completely cures the disease, but a skillful combination of lifestyle measures and sometimes also medical treatment can take away most symptoms.

The symptoms of fibromyalgia can make it difficult to attain an active lifestyle. Yet, to do work, sport activities and hobby activities will decrease the symptoms and the consequences of the disease.

Regular training will greatly decrease the symptoms of the disease. The training should engage all the muscles of the body and also include exercises that improve the condition.

A combination of muscle strength training as for example weight-lifting and condition training as jogging will be especially useful. Swimming exercises both the muscular strength and the condition at the same time, but the water should not be cold.

In the beginning, the training sessions should be short and easy, but they should be made longer and heavier as one gets used to training activities.

Relaxation techniques like autogenous training and meditation can help to normalize the function of the nervous system and increase the blood flow to the muscles.

Physical yoga can help to reduce stiffness, increase the blood flow and reduce anatomical defects in the joints and muscles.

The symptoms of fibromyalgia will often cause sufferers to believe that they manage less than they actually do. It may be useful for the sufferer from fibromyalgia to seek counselling to help him normalize his activity levels, or adopt a higher activity level compatible with his disease.

A healthy diet is important. The food should be as natural as possible, and include food sources like: Vegetables, fruit, full corn bread or cereals, nuts, almonds, fish, seafood, fouls and mushrooms.

You should avoid great amounts of fat meat, fat cheese or saturated fat from milk and red meat. You should also avoid great amounts of soy oil or corn oil. You should not use margarine and avoid food containing chemically altered fat. Great amounts of all the mentioned fat types tend to deteriorate the blood circulation and increase inflammatory reactions.

You should consume fish oil, olive oil, rape oil, canola oil, nut oil and sunflower oil, or food containing these type of fat like olives, nuts, sunflower seeds and fat fish, because the fat you then consume will decrease inflammatory reactions in the muscles and joint areas.

MEDICAL TREATMENT OF FIBROMYALGIA

Certain types of medication can be used to relieve the symptoms for a time, but should generally not be used permanently:

Analgesics can reduce the pain in the tender points.

Antidepressant can help to take away depressive feelings and improve the sleep.

Muscle relaxant at bedtime can help to relax during sleep.

On the market you will also find alternative drugs to treat fibromyalgia, based on herbs, vitamins, minerals and anti-oxidants. These drugs contain ingredients to give several useful effects:

To repair nutritional deficiencies found by fibromyalgia

To normalize the production of neurotransmitters and thereby improve the local blood circulation in muscles and joint surroundings.

To improve sleep and relaxation in the muscles during sleep.

To help for tiredness.

To reduce pain by an analgesic effect.

Examples of ingredients found in such medicines are:

Magnesium – To cure deficiency in the body’s magnesium level.

5-HTP – A serotonin precursor to help against serotonin deficiency and thereby improve local blood circulation.

Melatonin – To improve sleep and relaxation during sleep.

Rhodiola Rosea extract – To help against fatigue.

Ginger Root – To treat pain and inflammation in muscles and joints.

Classical massage or other types of physical therapi, for example a couple of times each week, can also help to increase blood flow, reduce tension, reduce stiffness and thereby take away pain.

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What is fibromyalgia
fibromyalgia (FM) is a human disorder classified by the presence of chronic widespread pain and tactile allodynia.[1] While the criteria for such an entity have not yet been thoroughly developed, the recognition that fibromyalgia involves more than just pain has led to the frequent use of the term “fibromyalgia syndrome”. It is not contagious, and recent studies suggest that people with fibromyalgia may be genetically predisposed.[2] The disorder is not directly life-threatening.

Do you have pain from head to toe? Are you tossing and turning throughout the night, unable to sleep? Do you wake up to pain and a foggy brain in the morning? These are common symptoms experienced by fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS) patients.The most common sites of pain include the neck, back, shoulders, pelvic girdle, and hands, but any body part can be affected. Fibromyalgia patients experience a range of symptoms of varying intensities that wax and wane over time.

Signs and symptoms
Widespread pain. Fibromyalgia is characterized by pain in specific areas of your body when pressure is applied, including the back of your head, upper back and neck, upper chest, elbows, hips and knees. The pain generally persists for months at a time and is often accompanied by stiffnessYou may have some degree of constant pain, but the pain may get worse in response to activity, stress, weather changes and other factors. You may have a deep ache or a burning pain. You may have muscle tightening or spasms. Many people have migratory pain (pain that moves around the body).

Risk Factors of Fibromyalgia
One study reported that 28% of the children of mothers with fibromyalgia also develop the disorder. Offspring who developed fibromyalgia were no more likely to have psychological disorders than those who did not.

Primary fibromyalgia is the most common type. Many experts believe that fibromyalgia is not a disease but rather a chronic pain condition brought on by several abnormal body responses to stress. Physical injuries, emotional trauma, or viral infections such as Epstein-Barr may be triggers of the disorder, but none have proven to be a cause of primary fibromyalgia.It is believed that individuals with FM may have low levels of certain chemicals in the brain such as serotonin and norepinephrine. Low levels of these brain chemicals can cause depression and contribute to the pain and fatigue experienced in FM.

How is it treated?
Analgesics or “pain relievers” interact with receptors in the body to stop the sensation of pain from various sources. Analgesic drugs vary in strength and addiction potential from over-the-counter Tylenol to stronger prescription medications such as propoxyphene/acetaminophen (Darvocet) and tramadol (Ultram).

Lyrica: This is the first drug approved by the FDA specifically for the treatment of fibromyalgia. While this is a step forward, it is no cure. Lyrica has been shown to cut pain levels in half, but only in 30% of the people who took it.

Exercise. The emphasis is often on muscle conditioning and programs to improve aerobic fitness (such as swimming, cycling, walking and stationary cross-country ski machines) as well as physical therapy. Patients should be told that exercise is safe and effective. After an initial training period, the exercise regimen chosen should be done daily for 30 to 40 minutes.

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What is fibromyalgia? It’s an arthritis like condition that causes diffuse muscle pains and excessive fatigue in the sufferer. Surprisingly enough, it affects as many as 2-3% of the general population, primarily middle aged women, and is an important cause of missed days from work and loss of productivity. Previously, there hasn’t been an FDA approved fibromyalgia medication available to treat this condition. Prior treatments for fibromyalgia, focusing on reducing levels of pain through pain management, have been relatively ineffective in most patients. Plus, new treatments have been difficult to develop as the cause of this perplexing disease is still unknown.

Fortunately, the FDA just announced the approval of a new fibromyalgia medication called Lyrica to treat the symptoms of this condition.. Interestingly enough, this is not a new drug to the medical community.It’s been used to treat a variety of other conditions unrelated to fibromyalgia including pain associated with diabetic neuropathy, pain associated with shingles and treatment of partial seizures. This would be the drug’s first approval specifically for the treatment of fibromyalgia symptoms.

Before approving this drug, the FDA looked at the results of randomized, controlled, double-blind studies on over 1800 people before giving their support and approval for the use of Lyrica in fibromyalgia patients. This fibromyalgia medication was shown to decrease pain levels in patients affected with the condition as well as improve their ability to carry out their daily activities. Reduction in pain levels were seen as early as the first week of treatment and were associated with significant improvement in sleep patterns as well as improvement in levels of fatigue experienced during the daytime hours. Adverse effects included difficulty concentrating, dizziness, and daytime sleepiness. There were also some reports of visual changes, weight gain, and dry mouth in patients enrolled in the studies. The side effects experienced by the patients in the studies appeared to be dose dependent.

Could this be the answer that fibromyalgia sufferers have been looking for? It’s too early to tell, but the preliminary test results look optimistic. If you or someone you know suffers from this condition, you may want to ask your family doctor to tell you more about this newly approved fibromyalgia medication and ask him or her if it would be right for you.

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